Publications

News

Seneca HELIX supports Beagle Scientific - Seneca Innovation Annual Report 2023 (Oct 2023)

Whitepaper

Next Generation Protein-Protein Interaction Screening (Collaboration between Beagle and Next Interactions) 

Articles

What the growth of AI means for drug discovery (Feb 2024)

Why Canada's Promising Biotech Sector May Be At Risk (Dec 2023)

Boosting Canadian Innovation in a Competitive Biotech Landscape (Oct 2023)

Drug Hunter - 2021 Large Molecule Approvals (Feb 2022)

Top 10 Biotech Innovations (Dec 2020)

How Scientists are Finding Solutions to the COVID-19 Pandemic (Apr 2020)

Illustrations

BioPharm International (Jun 2022) 

News Medical Life Science (Mar 2022)

BioProcess International (Cover Illustration Feb 2022 Featured Report, Article: Development and Manufacture of Therapeutic Bispecific Antibodies)

Drug Hunter (Oct 2021) 

Drug Target Review (Apr 2021)

Drug Hunter - 2020 Small Molecule of the Year

Scientific Publications

Huen, J., Z. Yan, J. Iwashkiw, S. Dubey, M.C. Gimenez, M.E. Ortiz, S.V. Patel, M.D. Jones, A. Riazi, M. Terebiznik, S. Babaei, D. Shahinas. 2019 Nov. A novel Single Domain Antibody Targeting FliC flagellin of Salmonella enterica for effective inhibition of host cell invasion. Front Microbiol 10:2665

Rizzolo, K.*, J. Huen*, A. Kumar*, S. Phanse, J. Vlasblom, Y. Kakihara, H. Zeineddine, Z. Minic, J. Snider, M. Costanzo, C. L. Myers, W. Wang, C. Pons, I. Stagljar, C. Boone, M. Babu, W. A. Houry. Sep 2017. Chaperoning the proteome: Novel features of the chaperone cellular network revealed through systematic interaction mapping. Cell Reports 20(11):2735

Huen, J., C-L. Lin, B. Golzarroshan, W-L. Yi, W-Z. Yang, H. S. Yuan. Mar 2017. Structural insights into a unique dimeric DEAD-box helicase CshA that promotes RNA decay. Structure 25(11):469

Jeganathan A., V. Leong, L. Zhao, J. Huen, N. Nano, W. A. Houry, J. Ortega. May 2015. Yeast rvb1 and rvb2 proteins oligomerize as a conformationally variable dodecamer with low frequency. J Mol Biol 427(10):1875

Cheung, K. L., J. Huen, Y. Kakihara, W. A. Houry, and J. Ortega. Dec 2010. Alternative oligomeric states of the yeast Rvb1/Rvb2 complex induced by histidine tags. J Mol Biol 404:478

Cheung, K. L., J. Huen, W. A. Houry, and J. Ortega. Feb 2010. Comparison of the multiple oligomeric structures observed for the Rvb1 and Rvb2 proteins. Biochem Cell Biol 88:77

Huen, J., Y. Kakihara, F. Ugwu, K. L. Cheung, J. Ortega, and W. A. Houry. Feb 2010. Rvb1-Rvb2: essential ATP-dependent helicases for critical complexes. Biochem Cell Biol 88:29

Gribun, A.*, K. L. Cheung*, J. Huen*, J. Ortega, and W. A. Houry. Mar 2008. Yeast Rvb1 and Rvb2 are ATP-dependent DNA helicases that form a heterohexameric complex. J Mol Biol 376:1320

Zhao, R., Y. Kakihara, A. Gribun, J. Huen, G. Yang, M. Khanna, M. Costanzo, R. L. Brost, C. Boone, T. R. Hughes, C. M. Yip, and W. A. Houry. Feb 2008. Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation. J Cell Biol 180:563